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Women in the Buffalo, NY, Area Who Have Never Had Cancer Needed

We need African-American and Caucasian women living in, or willing to travel to, the Buffalo, New York, area who are postmenopausal, between the ages of 45 and 75 and have never had any type of cancer (except skin cancer) to participate in a study that is using flaxseed to look at the connections between race, genes, hormones, and breast cancer risk.

Studies suggest that certain hormones may be related to increased breast cancer risk, and that some foods may alter these hormones, which could help to reduce this risk. Flaxseed is a food that is rich in compounds that have hormone-like effects. A research team at Roswell Park Cancer Institute in Buffalo, NY, is investigating how eating flaxseed affects a woman’s normal intestinal bacteria, genes, and hormone levels. They are also looking at whether the effect differs between African-American and Caucasian women.

Please read on to learn more about what is involved and who can participate. And please don’t forget to tell any of your family members or friends in the Buffalo, New York, area about this study!

What’s the study about?

The purpose of this study is to determine whether adding flaxseed (a food high in compounds that can change hormones) to a regular diet changes hormones that are related to breast cancer risk and if the effect of flaxseed differs between African-American and Caucasian women.

What’s involved?

If you sign up for A Pilot Study of the Flaxseed Effects on Hormones and Lignans: Role of Race, Genes, and Gut Microbiome, the research team will contact you to confirm that you are eligible. If you choose to participate in the study, you will be asked to:

• Be randomly assigned (like the flip of a coin) to eat 2 tablespoons of ground flaxseed per day for 6 weeks or to maintain your usual diet. Two months later, you will switch into the other group for 6 weeks.

• Complete an interview about your diet, health habits, medical history, reproductive history, and other information related to a woman’s risk of developing breast cancer.

• Attend 5 morning visits throughout the duration of the study at the Prevention Center at Roswell Park Cancer Institute. At these visits, you will be asked to provide a blood sample and have your height, weight, and body fat measured. You will also be asked to bring a urine sample from the night before and a small sample of that day’s bowel movement that you collected at your home. The research team will provide the containers for these samples, and instructions on how to collect them. The research team will also call you periodically to ask you everything you ate and drank in the past 24 hours.

Who is conducting the study?

Susan McCann, PhD, Roswell Park Cancer Institute, in collaboration with Johanna Lampe, PhD, Fred Hutchinson Cancer Research Center


Roswell Park Cancer Institute, Buffalo, New York

Who can participate?

You can sign up for A Pilot Study of the Flaxseed Effects on Hormones and Lignans: Role of Race, Genes, and Gut Microbiome if you meet ALL of these MAIN criteria:

• You are a woman between 45 and 75 years of age.

• You have stopped having your menstrual periods (you are postmenopausal).

• Your last menstrual period was more than 12 months ago.

• You have never been diagnosed with any cancer (basal and squamous cell skin cancers are OK).

• You have never had gastric bypass surgery.

• You have NOT taken estrogen or other female hormones (hormone replacement therapy, nonprescription hormones, or herbal supplements for menopausal symptoms) within the past 2 months.

• You do NOT eat flaxseed or take a flaxseed supplement regularly.

• You are NOT allergic to seeds or nuts.

• You have NOT taken antibiotics in the last 3 months.

• You live near or are willing to travel (at your own expense) to Roswell Park Cancer Institute in Buffalo, New York.

• You self-identify as:
o Non-Hispanic White OR
o Non-Hispanic Black

After you RSVP, the research team will contact you to ask additional questions to be sure that the study is a good fit for you.

YES, SIGN ME UPYes, Sign Me Up


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